Chikusetsu Saponin V Attenuates MPP+-Induced Neurotoxicity in SH-SY5Y Cells via Regulation of Sirt1/Mn-SOD and GRP78/Caspase-12 Pathways

Studies have shown that saponins from Panax japonicus (SPJ) possess neuroprotective effects. However, whether Chikusetsu saponin V (CsV), the most abundant member of SPJ, can exert neuroprotective effects against 1-methyl-4-phenylpyridinium ion (MPP+)-induced cytotoxicity is not known. In this study...

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Autori principali: Ding Yuan, Jing-Zhi Wan, Li-Li Deng, Chang-Cheng Zhang, Yao-Yan Dun, Yan-Wen Dai, Zhi-Yong Zhou, Chao-Qi Liu, Ting Wang
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2014-07-01
Serie:International Journal of Molecular Sciences
Soggetti:
Chikusetsu saponin V
MPP+
Sirt1
GRP78
Accesso online:http://www.mdpi.com/1422-0067/15/8/13209
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