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Influenza infects lung microvascular endothelium leading to microvascular leak: role of apoptosis and claudin-5.

Severe influenza infections are complicated by acute lung injury, a syndrome of pulmonary microvascular leak. The pathogenesis of this complication is unclear. We hypothesized that human influenza could directly infect the lung microvascular endothelium, leading to loss of endothelial barrier functi...

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Detalhes bibliográficos
Main Authors: Susan M Armstrong, Changsen Wang, Jayesh Tigdi, Xiaoe Si, Carlo Dumpit, Steffany Charles, Asela Gamage, Theo J Moraes, Warren L Lee
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2012-01-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC3480371?pdf=render
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