Synaptic Interactome Mining Reveals p140Cap as a New Hub for PSD Proteins Involved in Psychiatric and Neurological Disorders

Altered synaptic function has been associated with neurological and psychiatric conditions including intellectual disability, schizophrenia and autism spectrum disorder (ASD). Amongst the recently discovered synaptic proteins is p140Cap, an adaptor that localizes at dendritic spines and regulates th...

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Main Authors: Annalisa Alfieri, Oksana Sorokina, Annie Adrait, Costanza Angelini, Isabella Russo, Alessandro Morellato, Michela Matteoli, Elisabetta Menna, Elisabetta Boeri Erba, Colin McLean, J. Douglas Armstrong, Ugo Ala, Joseph D. Buxbaum, Alfredo Brusco, Yohann Couté, Silvia De Rubeis, Emilia Turco, Paola Defilippi
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Molecular Neuroscience
Assuntos:
p140Cap
postsynaptic density
synaptic transmission
synaptic plasticity
schizophrenia
autism
Acceso en liña:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00212/full
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