Fatty acid-binding protein 4 is a therapeutic target for septic acute kidney injury by regulating inflammatory response and cell apoptosis

Upregulation of tubular FABP4 in septic AKI is dependent on TLR4/c-Jun signaling activation, and FABP4 mediates sepsis-induced RTEC injury, likely by forming a positive feedback loop with c-Jun to aggravate inflammation and apoptosis.

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Bo Wang, Jun Xu, Qian Ren, Lu Cheng, Fan Guo, Yan Liang, Letian Yang, Zhouke Tan, Ping Fu, Liang Ma
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2022-04-01
Serie:Cell Death and Disease
Länkar:https://doi.org/10.1038/s41419-022-04794-w
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk