Integrative analysis of mutated genes and mutational processes reveals novel mutational biomarkers in colorectal cancer

Abstract Background Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. Recent studies have observed causative mutations in susceptible genes related to colorectal cancer in 10 to 15% of the patients. This highlights the importance of identifying mutations for ea...

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Detalhes bibliográficos
Main Authors: Hamed Dashti, Iman Dehzangi, Masroor Bayati, James Breen, Amin Beheshti, Nigel Lovell, Hamid R. Rabiee, Hamid Alinejad-Rokny
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2022-04-01
Colecção:BMC Bioinformatics
Assuntos:
Colorectal cancer
Cancer subtype identification
Somatic point mutations
Motif analysis
Gene prioritization
Therapeutic targets
Acesso em linha:https://doi.org/10.1186/s12859-022-04652-8
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