Optimization of the antimicrobial peptide Bac7 by deep mutational scanning

Abstract Background Intracellularly active antimicrobial peptides are promising candidates for the development of antibiotics for human applications. However, drug development using peptides is challenging as, owing to their large size, an enormous sequence space is spanned. We built a high-throughp...

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Detalhes bibliográficos
Principais autores: Philipp Koch, Steven Schmitt, Alexander Heynisch, Anja Gumpinger, Irene Wüthrich, Marina Gysin, Dimitri Shcherbakov, Sven N. Hobbie, Sven Panke, Martin Held
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2022-05-01
coleção:BMC Biology
Assuntos:
Antibiotics
Antimicrobial peptides
Drug discovery
High-throughput screening
Antimicrobials
Deep mutational scanning
Acesso em linha:https://doi.org/10.1186/s12915-022-01304-4
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