Optimization of the antimicrobial peptide Bac7 by deep mutational scanning

Abstract Background Intracellularly active antimicrobial peptides are promising candidates for the development of antibiotics for human applications. However, drug development using peptides is challenging as, owing to their large size, an enormous sequence space is spanned. We built a high-throughp...

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書誌詳細
主要な著者: Philipp Koch, Steven Schmitt, Alexander Heynisch, Anja Gumpinger, Irene Wüthrich, Marina Gysin, Dimitri Shcherbakov, Sven N. Hobbie, Sven Panke, Martin Held
フォーマット: Artigo
言語:Inglês
出版事項: BMC 2022-05-01
シリーズ:BMC Biology
主題:
Antibiotics
Antimicrobial peptides
Drug discovery
High-throughput screening
Antimicrobials
Deep mutational scanning
オンライン･アクセス:https://doi.org/10.1186/s12915-022-01304-4
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