Optimization of the antimicrobial peptide Bac7 by deep mutational scanning

Abstract Background Intracellularly active antimicrobial peptides are promising candidates for the development of antibiotics for human applications. However, drug development using peptides is challenging as, owing to their large size, an enormous sequence space is spanned. We built a high-throughp...

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Hlavní autoři: Philipp Koch, Steven Schmitt, Alexander Heynisch, Anja Gumpinger, Irene Wüthrich, Marina Gysin, Dimitri Shcherbakov, Sven N. Hobbie, Sven Panke, Martin Held
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2022-05-01
Edice:BMC Biology
Témata:
Antibiotics
Antimicrobial peptides
Drug discovery
High-throughput screening
Antimicrobials
Deep mutational scanning
On-line přístup:https://doi.org/10.1186/s12915-022-01304-4
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