Autocrine Human Growth Hormone Promotes Invasive and Cancer Stem Cell-Like Behavior of Hepatocellular Carcinoma Cells by STAT3 Dependent Inhibition of CLAUDIN-1 Expression

Despite progress in diagnosis and treatment of hepatocellular carcinoma (HCC), the clinical outcome is still unsatisfactory. Increased expression of human growth hormone (hGH) in HCC has been reported and is associated with poor survival outcome in HCC patients. Herein, we investigated the mechanism...

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Bibliografski detalji
Glavni autori: Yi-Jun Chen, Ming-Liang You, Qing-Yun Chong, Vijay Pandey, Qiu-Shi Zhuang, Dong-Xu Liu, Lan Ma, Tao Zhu, Peter E. Lobie
Format: Artigo
Jezik:Inglês
Izdano: MDPI AG 2017-06-01
Serija:International Journal of Molecular Sciences
Teme:
human growth hormone
hepatocellular carcinoma
STAT3
CLAUDIN-1
cancer stem cells
Online pristup:http://www.mdpi.com/1422-0067/18/6/1274
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