Circular RNA circ-MTHFD1L induces HR repair to promote gemcitabine resistance via the miR-615-3p/RPN6 axis in pancreatic ductal adenocarcinoma

Abstract Background Chemoresistance of pancreatic cancer is the main reason for the poor treatment effect of pancreatic cancer patients. Exploring chemotherapy resistance-related genes has been a difficult and hot topic of oncology. Numerous studies implicate the key roles of circular RNAs (circRNAs...

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Main Authors: Zhi-Wen Chen, Jian-Fei Hu, Zu-Wei Wang, Cheng-Yu Liao, Feng-Ping Kang, Cai-Feng Lin, Yi Huang, Long Huang, Yi-Feng Tian, Shi Chen
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2022-04-01
Colecção:Journal of Experimental & Clinical Cancer Research
Assuntos:
Circ-MTHFD1L
miR-615-3p
RPN6
Gemcitabine resistance
Pancreatic cancer
Acesso em linha:https://doi.org/10.1186/s13046-022-02343-z
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