Hyperactivity and Hypermotivation Associated With Increased Striatal mGluR1 Signaling in a Shank2 Rat Model of Autism

Mutations in the SHANK family of genes have been consistently identified in genetic and genomic screens of autism spectrum disorder (ASD). The functional overlap of SHANK with several other ASD-associated genes suggests synaptic dysfunction as a convergent mechanism of pathophysiology in ASD. Althou...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Meera E. Modi, Julie M. Brooks, Edward R. Guilmette, Mercedes Beyna, Radka Graf, Dominik Reim, Michael J. Schmeisser, Tobias M. Boeckers, Patricio O’Donnell, Derek L. Buhl
التنسيق: Artigo
اللغة:Inglês
منشور في: Frontiers Media S.A. 2018-06-01
سلاسل:Frontiers in Molecular Neuroscience
الموضوعات:
SHANK
Shank2
autism spectrum disorders
rat model
mGluR
motivation
الوصول للمادة أونلاين:https://www.frontiersin.org/article/10.3389/fnmol.2018.00107/full
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