Tumor suppressor WWOX and p53 alterations and drug resistance in glioblastomas

Tumor suppressor p53 are frequently mutated in glioblastomas (GBMs) and appears to contribute, in part, to resistance to temozolomide and therapeutic drugs. WW domain-containing oxidoreductase WWOX (FOR or WOX1) is a proapoptotic protein and is considered as a tumor suppressor. Loss of WWOX gene exp...

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Bibliografski detalji
Glavni autori: Ming-Fu eChiang, Pei-Yi eChou, Wan-Jen eWang, Chun-I eSze, Nan-Shan eChang
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2013-03-01
Serija:Frontiers in Oncology
Teme:
p53
tumor suppressor
Glioblastoma Multiforme
WWOX
temozolomide resistance
Online pristup:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00043/full
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