DHW-221, a Dual PI3K/mTOR Inhibitor, Overcomes Multidrug Resistance by Targeting P-Glycoprotein (P-gp/ABCB1) and Akt-Mediated FOXO3a Nuclear Translocation in Non-small Cell Lung Cancer

Multidrug resistance (MDR) is considered as a primary hindrance for paclitaxel failure in non-small cell lung cancer (NSCLC) patients, in which P-glycoprotein (P-gp) is overexpressed and the PI3K/Akt signaling pathway is dysregulated. Previously, we designed and synthesized DHW-221, a dual PI3K/mTOR...

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Autores principales: Mingyue Liu, Chang Xu, Xiaochun Qin, Wenwu Liu, Deping Li, Hui Jia, Xudong Gao, Yuting Wu, Qiong Wu, Xiangbo Xu, Bo Xing, Xiaowen Jiang, Hongyuan Lu, Yingshi Zhang, Huaiwei Ding, Qingchun Zhao
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2022-05-01
Colección:Frontiers in Oncology
Materias:
NSCLC
P-glycoprotein
FOXO3a nuclear translocation
Multidrug resistance
DHW-221
paraptosis
Acceso en línea:https://www.frontiersin.org/articles/10.3389/fonc.2022.873649/full
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