A Single Shot Pre-fusion-Stabilized Bovine RSV F Vaccine is Safe and Effective in Newborn Calves with Maternally Derived Antibodies

Achieving safe and protective vaccination against respiratory syncytial virus (RSV) in infants and in calves has proven a challenging task. The design of recombinant antigens with a conformation close to their native form in virus particles is a major breakthrough. We compared two subunit vaccines,...

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Main Authors: Sabine Riffault, Sara Hägglund, Efrain Guzman, Katarina Näslund, Luc Jouneau, Catherine Dubuquoy, Vincent Pietralunga, Daphné Laubreton, Olivier Boulesteix, David Gauthier, Aude Remot, Abdelhak Boukaridi, Alexander Falk, Ganna Shevchenko, Sara Bergström Lind, Karin Vargmar, Baoshan Zhang, Peter D. Kwong, María Jose Rodriguez, Marga Garcia Duran, Isabelle Schwartz-Cornil, Jean-François Eléouët, Geraldine Taylor, Jean François Valarcher
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-05-01
Colecção:Vaccines
Assuntos:
bovine
neonate
pre-fusion conformation
respiratory syncytial virus
subunit vaccine
Acesso em linha:https://www.mdpi.com/2076-393X/8/2/231
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