Proteomics reveals a therapeutic vulnerability via the combined blockade of APE1 and autophagy in lung cancer A549 cells

Abstract Background Drug resistance is a major cause of therapeutic failure that is often associated with elevated autophagy and apurinic/apyrimidinic endonuclease 1 (APE1) expression. Herein, we investigated the role of APE1 and autophagy in A549 cells treated with cisplatin. Methods SILAC proteomi...

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Main Authors: Shu-Ting Pan, Ji Zhou, Fang Yang, Shu-Feng Zhou, Tao Ren
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2020-07-01
Colecção:BMC Cancer
Assuntos:
Cisplatin
APE1
Autophagy
Chemotherapy
Non-small cell lung cancer
Apoptosis
Acesso em linha:http://link.springer.com/article/10.1186/s12885-020-07111-w
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