Tetraspanin 7 promotes osteosarcoma cell invasion and metastasis by inducing EMT and activating the FAK-Src-Ras-ERK1/2 signaling pathway

Abstract Background Tetraspanins are members of the 4-transmembrane protein superfamily (TM4SF) that function by recruiting many cell surface receptors and signaling proteins into tetraspanin-enriched microdomains (TEMs) that play vital roles in the regulation of key cellular processes including adh...

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Hlavní autoři: Shijie Shao, Lianhua Piao, Liwei Guo, Jiangsong Wang, Luhui Wang, Jiawen Wang, Lei Tong, Xiaofeng Yuan, Junke Zhu, Sheng Fang, Yimin Wang
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2022-05-01
Edice:Cancer Cell International
Témata:
Tspan7
Osteosarcoma
Integrin β1
EMT
FAK-Src-Ras-ERK1/2 signaling pathway
On-line přístup:https://doi.org/10.1186/s12935-022-02591-1
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