Age-associated changes in the circulating human antibody repertoire are upregulated in autoimmunity

Abstract Background The immune system undergoes a myriad of changes with age. While it is known that antibody-secreting plasma and long-lived memory B cells change with age, it remains unclear how the binding profile of the circulating antibody repertoire is impacted. Results To understand humoral i...

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Bibliographic Details
Main Authors: Aaron Arvey, Michael Rowe, Joseph Barten Legutki, Gang An, Anantha Gollapudi, Anna Lei, Bill Colston, Chaim Putterman, David Smith, Janelle Stiles, Theodore Tarasow, Preveen Ramamoorthy
Format: Artigo
Language:Inglês
Published: BMC 2020-10-01
Series:Immunity & Ageing
Subjects:
Antibody binding profile
Immune age
Auto-immune disease
Machine learning
Immunosenescence
Antibody response
Online Access:http://link.springer.com/article/10.1186/s12979-020-00193-x
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