Flexible semiparametric joint modeling: an application to estimate individual lung function decline and risk of pulmonary exacerbations in cystic fibrosis

Abstract Background Epidemiologic surveillance of lung function is key to clinical care of individuals with cystic fibrosis, but lung function decline is nonlinear and often impacted by acute respiratory events known as pulmonary exacerbations. Statistical models are needed to simultaneously estimat...

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Detalhes bibliográficos
Main Authors: Dan Li, Ruth Keogh, John P. Clancy, Rhonda D. Szczesniak
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2017-11-01
Colecção:Emerging Themes in Epidemiology
Assuntos:
Bayesian analysis
Cystic fibrosis
Functional data analysis
Longitudinal studies
Mixed model analysis
Pulmonary decline
Acesso em linha:http://link.springer.com/article/10.1186/s12982-017-0067-1
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