Neuronal surface P antigen (NSPA) modulates postsynaptic NMDAR stability through ubiquitination of tyrosine phosphatase PTPMEG

Abstract Background Cognitive dysfunction (CD) is common among patients with the autoimmune disease systemic lupus erythematosus (SLE). Anti-ribosomal P autoantibodies associate with this dysfunction and have neuropathogenic effects that are mediated by cross-reacting with neuronal surface P antigen...

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Detalhes bibliográficos
Main Authors: Sofía Espinoza, Sebastián B. Arredondo, Francisca Barake, Francisco Carvajal, Fernanda G. Guerrero, Fabian Segovia-Miranda, David M. Valenzuela, Ursula Wyneken, Alejandro Rojas-Fernández, Waldo Cerpa, Loreto Massardo, Lorena Varela-Nallar, Alfonso González
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2020-11-01
Colecção:BMC Biology
Assuntos:
NMDA receptor
GluN2B Tyr1472
Tyrosine phosphatase PTPMEG/PTPN4
Synaptic plasticity
Memory
Postsynaptic densities
Acesso em linha:http://link.springer.com/article/10.1186/s12915-020-00877-2
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