Proteomic analysis reveals exercise training induced remodelling of hepatokine secretion and uncovers syndecan-4 as a regulator of hepatic lipid metabolism

Objective: Non-alcoholic fatty liver disease (NAFLD) is linked to impaired lipid metabolism and systemic insulin resistance, which is partly mediated by altered secretion of liver proteins known as hepatokines. Regular physical activity can resolve NAFLD and improve its metabolic comorbidities, howe...

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Main Authors: William De Nardo, Paula M. Miotto, Jacqueline Bayliss, Shuai Nie, Stacey N. Keenan, Magdalene K. Montgomery, Matthew J. Watt
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2022-06-01
Series:Molecular Metabolism
Assuntos:
Exercise
Hepatokine
Syndecan-4
Non-alcoholic fatty liver disease
Hepatic steatosis
Lipid metabolism
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2212877822000606
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