Angiotensin-Converting Enzyme 2 Attenuates Bleomycin-Induced Lung Fibrosis in Mice

Background: Local renin-angiotensin system (RAS) activation has been shown to play an important role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). It has been reported that angiotensin-converting enzyme 2 (ACE2) could inhibit RAS-mediated epithelial injury and fibrogenesis and that ACE...

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Bibliographic Details
Main Authors: Lifang Wang, Yuxiang Wang, Tuo Yang, Yanfei Guo, Tieying Sun
Format: Artigo
Language:Inglês
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-05-01
Series:Cellular Physiology and Biochemistry
Subjects:
Bleomycin
RAS
ACE2
Lung fibrosis
Alveolitis
Online Access:http://www.karger.com/Article/FullText/430131
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