Membrane damage elicits an immunomodulatory program in Staphylococcus aureus.

The Staphylococcus aureus HrtAB system is a hemin-regulated ABC transporter composed of an ATPase (HrtA) and a permease (HrtB) that protect S. aureus against hemin toxicity. S. aureus strains lacking hrtA exhibit liver-specific hyper-virulence and upon hemin exposure over-express and secrete immunom...

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Bibliographic Details
Main Authors: Ahmed S Attia, Meredith A Benson, Devin L Stauff, Victor J Torres, Eric P Skaar
Format: Artigo
Language:Inglês
Published: Public Library of Science (PLoS) 2010-03-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2837406?pdf=render
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