Integral membrane pyrophosphatases: a novel drug target for human pathogens?

Membrane-integral pyrophosphatases (mPPases) are found in several human pathogens, including <em>Plasmodium</em> species, the protozoan parasites that cause malaria. These enzymes hydrolyze pyrophosphate and couple this to the pumping of ions (H<sup>+</sup> and/or Na<sup&g...

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Bibliografski detalji
Glavni autori: Henri Xhaard, Keni Vidilaseris, Nita R. Shah, Adrian Goldman
Format: Artigo
Jezik:Inglês
Izdano: AIMS Press 2016-03-01
Serija:AIMS Biophysics
Teme:
pyrophosphatase
structure-based drug design
membrane
human pathogens
malaria
Online pristup:http://www.aimspress.com/biophysics/article/665/fulltext.html
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