Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis

Autophagy is essential to endothelial cell homeostasis. Here the authors show that lipophagy in LEC supports fatty acid oxidation to sustain a mitochondrial-Prox1 gene expression circuit and promote response of LEC to lymphangiogenic mediators.

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Autors principals: Odeta Meçe, Diede Houbaert, Maria-Livia Sassano, Tania Durré, Hannelore Maes, Marco Schaaf, Sanket More, Maarten Ganne, Melissa García-Caballero, Mila Borri, Jelle Verhoeven, Madhur Agrawal, Kathryn Jacobs, Gabriele Bergers, Silvia Blacher, Bart Ghesquière, Mieke Dewerchin, Johan V. Swinnen, Stefan Vinckier, María S. Soengas, Peter Carmeliet, Agnès Noël, Patrizia Agostinis
Format: Artigo
Idioma:Inglês
Publicat: Nature Portfolio 2022-05-01
Col·lecció:Nature Communications
Accés en línia:https://doi.org/10.1038/s41467-022-30490-6
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