Higher baseline global leukocyte DNA methylation is associated with MTX non-response in early RA patients

Abstract Background Low-dose methotrexate (MTX) is the first-line therapy in early rheumatoid arthritis (eRA). Up to 40% of eRA patients do not benefit from MTX therapy. MTX has been shown to inhibit one-carbon metabolism, which is involved in the donation of methyl groups. In this study, we investi...

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Detalhes bibliográficos
Main Authors: Helen R. Gosselt, Bertrand D. van Zelst, Maurits C. F. J. de Rotte, Johanna M. W. Hazes, Robert de Jonge, Sandra G. Heil
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-06-01
Colecção:Arthritis Research & Therapy
Assuntos:
DNA methylation
Arthritis
Tandem mass spectrometry
Methotrexate
Folic acid
Acesso em linha:http://link.springer.com/article/10.1186/s13075-019-1936-5
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