Optimization of Vaccine Virus Accumulation in the Development of Smallpox Drugs Based on Cell Cultures

Objective. Optimization of vaccine virus cultivation in the suspended cell culture BHK-21 for infectious activity increment of virus-containing suspension as the base material for smallpox vaccine preparations. Materials and methods. We used suspended culture line of the cells BHK-21 of 72-hour age...

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Main Authors: A. V. Ovchinnikov, G. V. Borisevich, A. I. Terent’ev, Yu. I. Pashchenko, V. T. Krotkov, V. N. Marchenko, S. V. Borisevich, S. L. Kuznetsov
Formato: Artigo
Idioma:Russo
Publicado: Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe” 2019-04-01
Series:Проблемы особо опасных инфекций
Assuntos:
culture of bhk-21 cells
virus of the vaccine
bioreactor
suspension cultivation of cells
Acceso en liña:https://journal.microbe.ru/jour/article/view/1132
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