The Interplay of Four Main Pathways Recomposes Immune Landscape in Primary and Metastatic Gastroenteropancreatic Neuroendocrine Tumors

BackgroundThe four major pathways in gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) including chromatin remodeling, DNA damage repair, activation of mTOR signaling, and telomere maintenance were mediated by some critical molecules and constituted critical processes of regulation in cance...

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Main Authors: Xin Lou, Heli Gao, Xiaowu Xu, Zeng Ye, Wuhu Zhang, Fei Wang, Jie Chen, Yue Zhang, Xuemin Chen, Yi Qin, Xianjun Yu, Shunrong Ji
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2022-05-01
Serija:Frontiers in Oncology
Teme:
gastroenteropancreatic neuroendocrine neoplasms
chromosomal instability
telomere maintenance
MTOR signaling
DNA damage repair
immune landscape
Online dostop:https://www.frontiersin.org/articles/10.3389/fonc.2022.808448/full
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