B-lymphocyte subpopulations in patients with rheumatoid arthritis and the effect of an interleukin-6 receptor inhibitor on them.

The clinical efficacy and safety of interleukin-6 (IL-6) receptor blockade have been well studied, but the data on the impact of therapeutic inhibition of IL-6 on B cells are scarce and contradictory. Preliminary reports have shown that B cell function and a humoral immune response may be modulated...

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Main Authors: E. V. Gerasimova, T. V. Popkova, A. P. Aleksankin, A. V. Martynova, E. L. Nasonov
Formato: Artigo
Idioma:Russo
Publicado: IMA-PRESS LLC 2019-01-01
Series:Научно-практическая ревматология
Assuntos:
rheumatoid arthritis
interleukin-6 receptor inhibitor
tocilizumab
cd19+ b cells
memory b cells
naive b cells
double negative b cells
flow cytometry
Acceso en liña:https://rsp.mediar-press.net/rsp/article/view/2650
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