New simple and quick method to analyze serum variant transthyretins: direct MALDI method for the screening of hereditary transthyretin amyloidosis

Abstract Background Hereditary transthyretin amyloidosis (ATTRv amyloidosis) is caused by a variant transthyretin (TTR), which is a serum protein secreted by the liver. Mass spectrometry (MS) is a useful tool that can detect variant TTRs in serum samples from patients with ATTRv amyloidosis. We prev...

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Hauptverfasser: Toshiya Nomura, Mitsuharu Ueda, Masayoshi Tasaki, Yohei Misumi, Teruaki Masuda, Yasuteru Inoue, Yukimoto Tsuda, Masamitsu Okada, Takahiro Okazaki, Kyosuke Kanenawa, Aito Isoguchi, Makoto Nakamura, Konen Obayashi, Satoru Shinriki, Hirotaka Matsui, Taro Yamashita, Yukio Ando
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2019-05-01
Schriftenreihe:Orphanet Journal of Rare Diseases
Schlagworte:
Hereditary transthyretin amyloidosis
Variant transthyretin
Mass spectrometry
Online Zugang:http://link.springer.com/article/10.1186/s13023-019-1100-y
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