KIF5C S176 Phosphorylation Regulates Microtubule Binding and Transport Efficiency in Mammalian Neurons.

Increased phosphorylation of the KIF5 anterograde motor is associated with impaired axonal transport and neurodegeneration, but paradoxically also with normal transport, though the details are not fully defined. JNK phosphorylates KIF5C on S176 in the motor domain; a site that we show is phosphoryla...

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Autores principales: Artur ePadzik, Prasannakumar eDeshpande, Patrik eHollos, Mariella eFranker, Emmy H. Rannikko, Dawen eCai, Piotr ePrus, Mats eMågård, Nina eWesterlund, Kristen J. Verhey, Peter eJames, Casper eHoogenraad, Eleanor T. Coffey
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2016-03-01
Colección:Frontiers in Cellular Neuroscience
Materias:
Axonal Transport
Axons
Brain
Kinesin
Mitogen-Activated Protein Kinases
Neurons
Acceso en línea:http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00057/full
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