Synergistic effects of 15-deoxy Δ12,14-prostaglandin J2 on the anti-tumor activity of doxorubicin in renal cell carcinoma

An endogenous anticancer agent, 15-deoxy -Δ12,14-prostaglandin J2 (15d-PGJ2) induces apoptosis in the chemoresistant renal cell carcinoma (RCC). Peroxisome proliferator-activated receptor-γ (PPARγ) is a nuclear receptor for 15d-PGJ2, and mediates the cytotoxicity of 15d-PGJ2 in many cancerous cells....

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Detalhes bibliográficos
Main Authors: Yasuhiro Yamamoto, Takehiro Yamamoto, Hiromi Koma, Ayaka Nishii, Tatsurou Yagami
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017-03-01
Colecção:Biochemistry and Biophysics Reports
Assuntos:
Renal cell carcinoma
15-deoxy Δ12,14-prostaglandin J2
Doxorubicin
Phosphoinositide 3-kinase
Chemoresistant
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2405580816302886
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