Involvement of the SIRT1/PGC-1α Signaling Pathway in Noise-Induced Hidden Hearing Loss

Objective: To establish an animal model of noise-induced hidden hearing loss (NIHHL), evaluate the dynamic changes in cochlear ribbon synapses and cochlear hair cell morphology, and observe the involvement of the SIRT1/PGC-1α signaling pathway in NIHHL.Methods: Male guinea pigs were randomly divided...

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Autori principali: Yu-Hui Liu, Yi-Hong Jiang, Cong-Cong Li, Xue-Min Chen, Li-Gui Huang, Min Zhang, Bai Ruan, Xiao-Cheng Wang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2022-05-01
Serie:Frontiers in Physiology
Soggetti:
cochlea
noise-induced hidden hearing loss
ribbon synapse
oxidative stress
Sirtuin 1
Accesso online:https://www.frontiersin.org/articles/10.3389/fphys.2022.798395/full
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