Aberrant insulin signaling in Alzheimer’s disease: current knowledge

Alzheimer’s disease (AD) is the most common form of dementia affecting elderly people. AD is a multifaceted pathology characterized by accumulation of extracellular neuritic plaques, intracellular neurofibrillary tangles (NFTs) and neuronal loss mainly in the cortex and hippocampus. AD etiology appe...

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Main Authors: Gaurav eBedse, Fabio eDi Domenico, Gaetano eServiddio, Tommaso eCassano
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2015-06-01
Series:Frontiers in Neuroscience
Assuntos:
Alzheimer’s disease
beta amyloid
insulin signaling
Insulin-like growth factor
phosphorylated tau
Acceso en liña:http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00204/full
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