vi-HMM: a novel HMM-based method for sequence variant identification in short-read data

Abstract Background Accurate and reliable identification of sequence variants, including single nucleotide polymorphisms (SNPs) and insertion-deletion polymorphisms (INDELs), plays a fundamental role in next-generation sequencing (NGS) applications. Existing methods for calling these variants often...

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Main Authors: Man Tang, Mohammad Shabbir Hasan, Hongxiao Zhu, Liqing Zhang, Xiaowei Wu
Formáid: Artigo
Teanga:Inglês
Foilsithe: BMC 2019-02-01
Sraith:Human Genomics
Ábhair:
HMM
Variant calling
SNP
INDEL
Viterbi algorithm
Rochtain Ar Líne:http://link.springer.com/article/10.1186/s40246-019-0194-6
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