Downregulation of hypermethylated in cancer-1 by miR-4532 promotes adriamycin resistance in breast cancer cells

Abstract Background MicroRNAs are small RNAs (~ 22 nt) that modulate the expression of thousands of genes in tumors and play important roles in the formation of multidrug resistance. In this study, we firstly investigated that miR-4532 involved in the multidrug resistance formation of breast cancer...

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Hauptverfasser: Fan Feng, Xiaolan Zhu, Chunyan Wang, Liang Chen, Weiping Cao, Yueqin Liu, Qi Chen, Wenlin Xu
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2018-09-01
Schriftenreihe:Cancer Cell International
Schlagworte:
miR-4532
Breast cancer
Multidrug resistance
Hypermethylated in cancer-1
Interleukin-6/signal transducer and activator of transcription 3 pathway
Online Zugang:http://link.springer.com/article/10.1186/s12935-018-0616-x
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