Protective effects of tadalafil on damaged podocytes in an adriamycin-induced nephrotic syndrome model

Podocyte injury is responsible for nephrotic syndrome. Previously, we found that tadalafil, a phosphodiesterase 5 inhibitor, might have protective effects on podocytes. Here, we investigated the effects of tadalafil in a nephrotic syndrome model and human podocyte cells.We divided adriamycin (ADR)-i...

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Bibliographic Details
Main Authors: Natsumi Tomita, Yuji Hotta, Aya Naiki-Ito, Akimasa Sanagawa, Tomoya Kataoka, Yoko Furukawa-Hibi, Satoru Takahashi, Kazunori Kimura
Format: Artigo
Language:Inglês
Published: Elsevier 2022-06-01
Series:Journal of Pharmacological Sciences
Subjects:
Nephrotic syndrome
Podocyte injury
PDE5 inhibitor
Animal model
Glomerular filtration barrier
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861322000238
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