Autophagy and protein aggregation as a mechanism of dopaminergic degeneration in a primary human dopaminergic neuronal model

The pathophysiology underlying the loss of dopaminergic neurons in Parkinson’s disease (PD) is unclear. A gap of knowledge in the molecular and cellular events leading to degeneration of the nigrostriatal DA system is a major barrier to the development of effective therapies for PD. 1-methyl-4-pheny...

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Main Authors: Elvis Cuevas, Aida Guzman, Susan M. Burks, Alejandro Ramirez-Lee, Syed F. Ali, Syed Z. Imam
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2022-01-01
Colecção:Toxicology Reports
Assuntos:
MPP+
Parkinson's disease
In vitro model
Autophagy
Protein aggregation
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2214750022000750
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