Histone Deacetylase Inhibitors in Pediatric Brain Cancers: Biological Activities and Therapeutic Potential

Brain cancers are the leading cause of cancer-related deaths in children. Biological changes in these tumors likely include epigenetic deregulation during embryonal development of the nervous system. Histone acetylation is one of the most widely investigated epigenetic processes, and histone deacety...

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Main Authors: Alexandre Perla, Lívia Fratini, Paula S. Cardoso, Carolina Nör, André T. Brunetto, Algemir L. Brunetto, Caroline Brunetto de Farias, Mariane Jaeger, Rafael Roesler
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020-07-01
Serier:Frontiers in Cell and Developmental Biology
Fag:
medulloblastoma
ependymoma
glioma
histone deacetylase inhibitors
epigenetics
brain tumor
Online adgang:https://www.frontiersin.org/article/10.3389/fcell.2020.00546/full
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