p62/Sequestosome-1 Is Indispensable for Maturation and Stabilization of Mallory-Denk Bodies.

Mallory-Denk bodies (MDBs) are hepatocytic protein aggregates found in steatohepatitis and several other chronic liver diseases as well as hepatocellular carcinoma. MDBs are mainly composed of phosphorylated keratins and stress protein p62/Sequestosome-1 (p62), which is a common component of cytopla...

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Autors principals: Pooja Lahiri, Volker Schmidt, Claudia Smole, Iris Kufferath, Helmut Denk, Pavel Strnad, Thomas Rülicke, Leopold F Fröhlich, Kurt Zatloukal
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science (PLoS) 2016-01-01
Col·lecció:PLoS ONE
Accés en línia:http://europepmc.org/articles/PMC4985067?pdf=render
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