The Citrus Flavonoid Hesperetin Has an Inadequate Anti-Arrhythmic Profile in the ΔKPQ Na<sub>V</sub>1.5 Mutant of the Long QT Type 3 Syndrome

Type 3 long QT syndromes (LQT3) are associated with arrhythmogenic gain-of-function mutations in the cardiac voltage-gated Na<sup>+</sup> channel (hNa<sub>V</sub>1.5). The citrus flavanone hesperetin (HSP) was previously suggested as a template molecule to develop new anti-ar...

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Main Authors: Julio Alvarez-Collazo, Alejandro López-Requena, Julio L. Alvarez, Karel Talavera
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2020-06-01
Series:Biomolecules
Assuntos:
hesperetin
flavonoid
citrus
human cardiac Na<sup>+</sup> channel
Na<sub>V</sub>1.5
genetic variant
Acceso en liña:https://www.mdpi.com/2218-273X/10/6/952
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