Enhancer of Polycomb and the Tip60 complex repress hematological tumor initiation by negatively regulating JAK/STAT pathway activity

Myeloproliferative neoplasms (MPNs) are clonal hematopoietic disorders that cause excessive production of myeloid cells. Most MPN patients have a point mutation in JAK2 (JAK2V617F), which encodes a dominant-active kinase that constitutively triggers JAK/STAT signaling. In Drosophila, this pathway is...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Alessandro A. Bailetti, Lenny J. Negrón-Piñeiro, Vishal Dhruva, Sneh Harsh, Sean Lu, Aisha Bosula, Erika A. Bach
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Company of Biologists 2019-05-01
Cyfres:Disease Models & Mechanisms
Pynciau:
JAK/STAT
Myeloproliferative neoplasms
Drosophila
E(Pc)
Tip60
Melanotic tumors
Lysine acetyltransferases
Tumor suppressor
Mynediad Ar-lein:http://dmm.biologists.org/content/12/5/dmm038679
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg