Enhancer of Polycomb and the Tip60 complex repress hematological tumor initiation by negatively regulating JAK/STAT pathway activity

Myeloproliferative neoplasms (MPNs) are clonal hematopoietic disorders that cause excessive production of myeloid cells. Most MPN patients have a point mutation in JAK2 (JAK2V617F), which encodes a dominant-active kinase that constitutively triggers JAK/STAT signaling. In Drosophila, this pathway is...

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Detalhes bibliográficos
Main Authors: Alessandro A. Bailetti, Lenny J. Negrón-Piñeiro, Vishal Dhruva, Sneh Harsh, Sean Lu, Aisha Bosula, Erika A. Bach
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2019-05-01
Colecção:Disease Models & Mechanisms
Assuntos:
JAK/STAT
Myeloproliferative neoplasms
Drosophila
E(Pc)
Tip60
Melanotic tumors
Lysine acetyltransferases
Tumor suppressor
Acesso em linha:http://dmm.biologists.org/content/12/5/dmm038679
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