Deciphering the Immune Complexity in Esophageal Adenocarcinoma and Pre-Cancerous Lesions With Sequential Multiplex Immunohistochemistry and Sparse Subspace Clustering Approach

Esophageal adenocarcinoma (EAC) develops from a chronic inflammatory environment across four stages: intestinal metaplasia, known as Barrett’s esophagus, low- and high-grade dysplasia, and adenocarcinoma. Although the genomic characteristics of this progression have been well defined via large-scale...

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Detalhes bibliográficos
Main Authors: Srinand Sundaram, Eun Na Kim, Georgina M. Jones, Shamilene Sivagnanam, Monika Tripathi, Ahmad Miremadi, Massimiliano Di Pietro, Lisa M. Coussens, Rebecca C. Fitzgerald, Young Hwan Chang, Lizhe Zhuang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-05-01
Colecção:Frontiers in Immunology
Assuntos:
multiplex imaging
sparse subspace clustering
immune complexity
esophageal adenocarcinoma
Barrett’s esophagus
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2022.874255/full
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