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Lipopolysaccharide Increases Cortical Kynurenic Acid and Deficits in Reference Memory in Mice

Kynurenic acid (KYNA), a glial-derived metabolite of tryptophan metabolism, is an antagonist of the alpha 7 nicotinic acetylcholine receptor and the glycine-binding site of N -methyl- d -aspartate (NMDA) receptors. Kynurenic acid levels are increased in both the brain and cerebrospinal fluid of seve...

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Hlavní autoři: Lee Peyton, Alfredo Oliveros, Maximilian Tufvesson-Alm, Lilly Schwieler, Phillip Starski, Göran Engberg, Sopie Erhardt, Doo-Sup Choi
Médium: Artigo
Jazyk:Inglês
Vydáno: SAGE Publishing 2019-12-01
Edice:International Journal of Tryptophan Research
On-line přístup:https://doi.org/10.1177/1178646919891169
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