Identification of key candidate targets and pathways for the targeted treatment of leukemia stem cells of chronic myelogenous leukemia using bioinformatics analysis

Abstract Background Chronic myelogenous leukemia (CML) is a myeloproliferative neoplasm that arises from the acquisition of constitutively active BCR‐ABL tyrosine kinase in hematopoietic stem cells. The persistence of bone marrow leukemia stem cells (LSCs) is the main cause of TKI resistance and CML...

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Bibliographic Details
Main Authors: Huayao Li, Lijuan Liu, Jing Zhuang, Cun Liu, Chao Zhou, Jing Yang, Chundi Gao, Gongxi Liu, Changgang Sun
Format: Artigo
Language:Inglês
Published: Wiley 2019-09-01
Series:Molecular Genetics & Genomic Medicine
Subjects:
bioinformatics
chronic myeloid leukemia
differentially expressed genes
differentially expressed microRNAs
gene chip
leukemia stem cells
Online Access:https://doi.org/10.1002/mgg3.851
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