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Design, Synthesis, and Antitumor Activity of Erlotinib Derivatives

Nineteen erlotinib derivatives bearing different 1,2,3-triazole moieties were designed, synthesized, and evaluated for their potential against different cancer cell lines. The structures of the synthesized compounds were confirmed via1H NMR, 13C NMR, and HR MS. Preliminary antitumor activity assay r...

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Main Authors: Long-fei Mao, Zhen-Zhen Wang, Qiong Wu, Xiaojie Chen, Jian-Xue Yang, Xin Wang, Yue-Ming Li
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2022-04-01
Sraith:Frontiers in Pharmacology
Ábhair:
Rochtain Ar Líne:https://www.frontiersin.org/articles/10.3389/fphar.2022.849364/full
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