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A highly potent and selective inhibitor Roxyl-WL targeting IDO1 promotes immune response against melanoma

Indoleamine 2,3-dioxygenase 1 (IDO1) activity links to immune escape of cancers. Inhibition of IDO1 provides a new approach for cancer treatment. Most clinical IDO1 drugs show marginal efficacy as single agents. On basis of molecular docking and pharmacophore modelling, a novel inhibitor Roxyl-WL wa...

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Detalhes bibliográficos
Main Authors: Guangwei Xu, Tianqi Wang, Yongtao Li, Zhi Huang, Xin Wang, Jianyu Zheng, Shengyong Yang, Yan Fan, Rong Xiang
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis Group 2018-01-01
Colecção:Journal of Enzyme Inhibition and Medicinal Chemistry
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Acesso em linha:http://dx.doi.org/10.1080/14756366.2018.1471688
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