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A highly potent and selective inhibitor Roxyl-WL targeting IDO1 promotes immune response against melanoma
Indoleamine 2,3-dioxygenase 1 (IDO1) activity links to immune escape of cancers. Inhibition of IDO1 provides a new approach for cancer treatment. Most clinical IDO1 drugs show marginal efficacy as single agents. On basis of molecular docking and pharmacophore modelling, a novel inhibitor Roxyl-WL wa...
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Main Authors: | , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Taylor & Francis Group
2018-01-01
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Colecção: | Journal of Enzyme Inhibition and Medicinal Chemistry |
Assuntos: | |
Acesso em linha: | http://dx.doi.org/10.1080/14756366.2018.1471688 |
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