Antiallodynic effects of KDS2010, a novel MAO-B inhibitor, via ROS-GABA inhibitory transmission in a paclitaxel-induced tactile hypersensitivity model

Abstract Monoamine oxidase (MAO) inhibitors have been investigated for the treatment of neuropathic pain. Here, we assessed the antiallodynic effects of a novel MAO-B inhibitor, KDS2010, on paclitaxel (PTX)-induced mechanical hypersensitivity. Oral administration of KDS2010 effectively relieved PTX-...

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Main Authors: Su Eun Park, Chiranjivi Neupane, Chan Noh, Ramesh Sharma, Hyun Jin Shin, Thuy Linh Pham, Gyu-Seung Lee, Ki Duk Park, C. Justin Lee, Dong-Wook Kang, So Yeong Lee, Hyun-Woo Kim, Jin Bong Park
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2022-05-01
Serier:Molecular Brain
Fag:
KDS2010
MAO-B
Tactile Hypersensitivity
Paclitaxel
Online adgang:https://doi.org/10.1186/s13041-022-00924-9
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