A Combination of Cytokine-Induced Killer Cells With PD-1 Blockade and ALK Inhibitor Showed Substantial Intrinsic Variability Across Non-Small Cell Lung Cancer Cell Lines

BackgroundCancer heterogeneity poses a serious challenge concerning the toxicity and adverse effects of therapeutic inhibitors, especially when it comes to combinatorial therapies that involve multiple targeted inhibitors. In particular, in non-small cell lung cancer (NSCLC), a number of studies hav...

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Bibliographic Details
Main Authors: Yutao Li, Amit Sharma, Xiaolong Wu, Hans Weiher, Dirk Skowasch, Markus Essler, Ingo G. H. Schmidt-Wolf
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Oncology
Subjects:
cytokine-induced killer cells
immune checkpoint inhibition programmed cell death-1
anaplastic lymphoma kinase
immunotherapy
non-small cell lung cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.713476/full
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