Host immune response mediates changes in cagA copy number and virulence potential of Helicobacter pylori

Helicobacter pylori is the major risk factor for gastric cancer. H. pylori harboring the type IV secretion system (T4SS) and its effector CagA encoded on the cag pathogenicity Island (cagPAI) increases the risk. H. pylori PMSS1 has a multi-cagA genotype, modulating cagA copy number dynamically from...

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Bibliographic Details
Main Authors: Sungil Jang, Lori M. Hansen, Hanfu Su, Jay V. Solnick, Jeong-Heon Cha
Format: Artigo
Language:Inglês
Published: Taylor & Francis Group 2022-12-01
Series:Gut Microbes
Subjects:
Helicobacter pylori
cagA
cagY
virulence
immune response
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2022.2044721
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